Actin filament depolymerization

Across TCGA cell cohorts, RNA activity of the Actin filament depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R9B, ACTN1, and BCL9L, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament depolymerization activity versus PPP1R9B in LIVER (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PPP1R9B →	+1.087	+0.173	.003	.004	3	18
LUNG_NSCLC_LUSC	ACTN1 →	+2.091	+0.278	<.001	<.001	3	17
LUNG_NSCLC_LUSC	BCL9L →	+1.711	+0.180	.004	.003	3	16
OESOPHAGUS	MICAL3 →	+1.946	+0.189	<.001	<.001	3	16
SKIN	TWF2 →	+1.142	+0.193	<.001	<.001	3	16
LIVER	PARP3 →	+1.802	+0.216	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030042 vs PPP1R9B — LIVER

Explore this scatter interactively →