Actin filament depolymerization

Across TCGA cell cohorts, RNA activity of the Actin filament depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC30, TENT5A, and MAPKAPK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament depolymerization activity versus DNAJC30 in STOMACH (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DNAJC30 →	+0.792	+0.487	<.001	<.001	3	5
BLOOD_Leukemia	TENT5A →	+3.219	+0.235	<.001	.002	3	5
BLOOD_Leukemia	MAPKAPK3 →	+0.985	+0.200	.004	.003	3	5
BLOOD_Leukemia	PTDSS1 →	+0.730	+0.245	.001	.002	3	5
OVARY	TACC1 →	+1.192	+0.337	.003	.002	3	5
LIVER	CIAO2B →	+0.567	+0.307	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030042 vs DNAJC30 — STOMACH

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