Microvillus assembly

Across TCGA patient cohorts, RNA activity of the Microvillus assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUSD2, TIMP2, and CHERP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microvillus assembly activity versus SUSD2 in UCEC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUSD2 →	+0.571	+0.068	<.001	<.001	3	7
CCRCC	TIMP2 →	+0.659	+0.058	<.001	<.001	3	7
GBM	CHERP →	-0.312	-0.067	<.001	<.001	3	7
UCEC	USP10 →	-0.177	-0.062	.003	.001	3	7
LUAD	MRPL15 →	-0.416	-0.067	<.001	<.001	3	7
GBM	MRPL32 →	-0.357	-0.050	.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030033 vs SUSD2 — UCEC

Explore this scatter interactively →