Lamellipodium assembly

Across TCGA patient cohorts, RNA activity of the Lamellipodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, RASL12, and JAM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lamellipodium assembly activity versus CNRIP1 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNRIP1 →	+0.710	+0.184	<.001	.002	3	6
LSCC	RASL12 →	+0.697	+0.180	<.001	<.001	3	5
CCRCC	JAM3 →	+0.678	+0.153	<.001	.001	3	5
LSCC	NR2F2-AS1 →	+0.647	+0.165	<.001	<.001	3	5
CCRCC	CALCRL →	+0.882	+0.179	<.001	<.001	3	5
CCRCC	TMEM233 →	+0.578	+0.158	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030032 vs CNRIP1 — BRCA

Explore this scatter interactively →