Lamellipodium assembly

Across TCGA cell cohorts, RNA activity of the Lamellipodium assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTR2, RAC1, and ACTR3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTR2 grouped by Lamellipodium assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACTR2 →	-0.563	-0.446	.003	.005	3	8
LARGE_INTESTINE	RAC1 →	-0.414	-0.385	<.001	<.001	3	8
STOMACH	ACTR3 →	-0.420	-0.489	<.001	.001	3	7
CNS	TLN1 →	-0.347	-0.302	.001	.001	2	7
LARGE_INTESTINE	ARPC2 →	-0.290	-0.308	.003	.003	3	6
SOFT_TISSUE	NCKAP1 →	-0.355	-0.431	.005	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTR2 by Lamellipodium assembly activity — SOFT_TISSUE

Explore this box plot interactively →