Maintenance of cell polarity

Across TCGA cell cohorts, RNA activity of the Maintenance of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDHR1, SUV39H1, and ARMC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDHR1 grouped by Maintenance of cell polarity-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CDHR1 →	-0.666	-0.279	.004	.004	3	4
LUNG_SCLC	SUV39H1 →	-0.806	-1.632	.004	.003	3	4
LUNG_SCLC	ARMC2 →	-0.832	-1.110	.003	.003	3	4
BLOOD_Lymphoma	ZNF551 →	-2.136	-0.591	.004	.008	3	4
LUNG_NSCLC_LUSC	ZNF418 →	-2.127	-1.693	.004	.001	3	3
LUNG_SCLC	ARL10 →	-2.236	-1.931	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDHR1 by Maintenance of cell polarity activity — OESOPHAGUS

Explore this box plot interactively →