Maintenance of cell polarity

Across TCGA cell cohorts, RNA activity of the Maintenance of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM1, DMD, and CPT1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of cell polarity activity versus PDLIM1 in BLOOD_Lymphoma (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PDLIM1 →	+5.441	+0.260	<.001	<.001	3	6
LIVER	DMD →	+3.125	+0.427	<.001	.001	3	4
SOFT_TISSUE	CPT1A →	-1.639	-0.198	.006	.002	2	5
STOMACH	CIB1 →	+1.561	+0.369	.005	.001	3	4
BLOOD_Lymphoma	CLEC2B →	+2.010	+0.172	<.001	<.001	3	4
BLOOD_Lymphoma	PLCL2 →	+1.482	+0.199	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030011 vs PDLIM1 — BLOOD_Lymphoma

Explore this scatter interactively →