Establishment of cell polarity

Across TCGA patient cohorts, RNA activity of the Establishment of cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL7, and EFEMP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of cell polarity activity versus RPL5 in CCRCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL5 →	-0.255	-0.030	<.001	<.001	3	7
CCRCC	RPL7 →	-0.222	-0.025	.006	<.001	3	7
OV	EFEMP2 →	+0.664	+0.046	.001	<.001	3	6
PDAC	SEC23B →	-0.180	-0.017	.007	.008	3	6
COAD	LARP4B_S736 →	-0.312	-0.017	.004	.004	3	6
CCRCC	RPL32 →	-0.377	-0.022	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030010 vs RPL5 — CCRCC

Explore this scatter interactively →