Establishment of cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment of cell polarity pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPP10, SGK2, and CTNNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPP10 grouped by Establishment of cell polarity-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DPP10 →	+0.506	+0.386	.004	.007	3	5
STOMACH	SGK2 →	-0.274	-0.177	.004	.001	3	5
PANCREAS	CTNNB1 →	-0.414	-0.179	.002	.008	3	5
PANCREAS	NF2 →	+0.190	+0.205	.001	.002	3	5
BLOOD_Myeloma	COL19A1 →	+0.331	+0.230	<.001	.003	3	4
URINARY_TRACT	RPA1 →	-0.837	-0.227	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPP10 by Establishment of cell polarity activity — BLOOD_Lymphoma

Explore this box plot interactively →