Establishment of cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLE4, DDX18, and SMIM26, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLE4 grouped by Establishment of cell polarity-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	POLE4 →	-0.937	-0.302	.005	.003	3	5
BLOOD_Leukemia	DDX18 →	-0.627	-0.158	.006	.004	3	4
BLOOD_Myeloma	SMIM26 →	+0.786	+0.317	.004	.004	2	5
LUNG_SCLC	NRXN2 →	-2.792	-0.165	.004	.005	3	4
PANCREAS	SPATA25 →	+0.565	+0.274	.005	.002	2	4
UPPER_AERODIGESTIVE_TRACT	LRRC56 →	+1.018	+0.183	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLE4 by Establishment of cell polarity activity — URINARY_TRACT

Explore this box plot interactively →