Establishment of cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSF2, PRSS36, and PARL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of cell polarity activity versus ACSF2 in BREAST (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACSF2 →	-2.197	-0.220	.001	.001	3	6
LUNG_NSCLC_LUAD	PRSS36 →	-0.426	-0.115	.005	.007	3	5
OVARY	PARL →	-0.738	-0.212	.001	<.001	3	5
URINARY_TRACT	HOOK2 →	-1.821	-0.400	<.001	.002	3	5
SOFT_TISSUE	CHD3 →	+1.600	+0.228	.005	.003	3	5
LUNG_NSCLC_LUSC	H4C5 →	-0.894	-0.191	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030010 vs ACSF2 — BREAST

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