Intracellular potassium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular potassium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1B1, SLC12A2, and MGAT1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular potassium ion homeostasis activity versus ATP1B1 in UVM (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ATP1B1 →	+1.570	+0.037	<.001	<.001	3	20
ESCA	SLC12A2 →	+1.582	+0.119	<.001	<.001	3	20
CHOL	MGAT1 →	-0.692	-0.113	<.001	<.001	3	19
SARC	CD300C →	-0.941	-0.044	<.001	<.001	3	19
SARC	HCST →	-1.149	-0.039	<.001	<.001	3	18
PAAD	LIMD2 →	-0.938	-0.041	<.001	.003	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030007 vs ATP1B1 — UVM

Explore this scatter interactively →