Intracellular potassium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular potassium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GALNT7, SLC12A2, and SLC12A2_S77, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular potassium ion homeostasis activity versus GALNT7 in UCEC (Pearson r = 0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GALNT7 →	+0.543	+0.071	.001	.006	3	7
PDAC	SLC12A2 →	+0.803	+0.098	<.001	<.001	3	6
PDAC	SLC12A2_S77 →	+0.831	+0.100	<.001	<.001	3	6
COAD	AGR2 →	+1.142	+0.072	<.001	<.001	3	6
UCEC	DOP1B →	+0.256	+0.081	.003	.001	3	6
GBM	ARHGAP26 →	+0.223	+0.062	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030007 vs GALNT7 — UCEC

Explore this scatter interactively →