Intracellular potassium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular potassium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, AZGP1, and GOT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular potassium ion homeostasis activity versus SLC12A2 in PDAC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC12A2 →	+0.716	+0.224	<.001	.001	3	5
LUAD	AZGP1 →	+2.079	+0.500	.001	.009	3	5
GBM	GOT1 →	+0.542	+0.481	<.001	<.001	3	5
LUAD	LINC01184 →	+0.650	+0.838	<.001	<.001	3	4
UCEC	ESRRG →	+0.944	+0.800	<.001	.004	3	4
LUAD	PRKAR1B-AS1 →	-0.606	-0.655	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030007 vs SLC12A2 — PDAC

Explore this scatter interactively →