Intracellular potassium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular potassium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF138, IFI27L1, and THUMPD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF138 grouped by Intracellular potassium ion homeostasis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RNF138 →	+1.077	+1.416	.001	<.001	3	3
SOFT_TISSUE	IFI27L1 →	-1.090	-1.361	.008	<.001	3	3
SOFT_TISSUE	THUMPD1 →	+0.750	+1.383	<.001	.001	3	3
LUNG_NSCLC_LUAD	TXNDC5 →	-0.483	-0.359	.002	.004	3	3
SKIN	RBM7 →	-0.587	-0.877	<.001	<.001	3	3
BLOOD_Myeloma	SELENON →	-1.569	-1.701	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF138 by Intracellular potassium ion homeostasis activity — SOFT_TISSUE

Explore this box plot interactively →