Intracellular potassium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular potassium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1A1, GPSM1, and GATA6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular potassium ion homeostasis activity versus ATP1A1 in LARGE_INTESTINE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP1A1 →	+1.090	+0.291	<.001	<.001	3	8
BLOOD_Leukemia	GPSM1 →	-1.629	-0.170	.009	.007	3	6
LARGE_INTESTINE	GATA6 →	+2.102	+0.329	<.001	<.001	3	5
LARGE_INTESTINE	ATP1B1 →	+1.312	+0.263	.001	<.001	3	5
BREAST	JAG1 →	+2.733	+0.313	<.001	.002	1	7
STOMACH	ATP1A3 →	-1.958	-0.311	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030007 vs ATP1A1 — LARGE_INTESTINE

Explore this scatter interactively →