Adaptation of signaling pathway

Across TCGA patient cohorts, RNA activity of the Adaptation of signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APLN, ZFP14, and IFT80, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adaptation of signaling pathway activity versus APLN in TGCT (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	APLN →	+1.895	+0.047	<.001	<.001	3	25
UVM	ZFP14 →	-0.629	-0.059	<.001	<.001	3	22
KIRP	IFT80 →	-0.747	-0.040	<.001	<.001	3	21
SKCM	TIA1 →	-0.895	-0.033	<.001	<.001	3	20
DLBC	NBPF12 →	-0.936	-0.093	<.001	<.001	2	21
DLBC	MBTD1 →	-0.791	-0.072	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023058 vs APLN — TGCT

Explore this scatter interactively →