Adaptation of signaling pathway

Across TCGA patient cohorts, RNA activity of the Adaptation of signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEBPZ, ESF1, and PDCD11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adaptation of signaling pathway activity versus CEBPZ in GBM (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEBPZ →	-0.341	-0.088	<.001	<.001	3	7
BRCA	ESF1 →	-0.369	-0.032	<.001	.002	3	7
LSCC	PDCD11 →	-0.360	-0.079	<.001	<.001	3	7
LSCC	TBL3 →	-0.185	-0.049	.006	<.001	3	6
BRCA	WDR43 →	-0.362	-0.042	<.001	<.001	3	6
GBM	XPO5 →	-0.526	-0.095	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023058 vs CEBPZ — GBM

Explore this scatter interactively →