Adaptation of signaling pathway

Across TCGA patient cohorts, RNA activity of the Adaptation of signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF831, CASP10, and GPRIN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adaptation of signaling pathway activity versus ZNF831 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF831 →	+0.382	+0.170	<.001	<.001	3	6
BRCA	CASP10 →	+0.433	+0.143	.001	<.001	3	5
UCEC	GPRIN3 →	+0.820	+0.153	.001	.001	3	5
UCEC	CCDC69 →	+0.718	+0.144	<.001	<.001	3	5
HNSC	PEBP1P3 →	+0.795	+0.167	.002	<.001	3	5
HNSC	FGD2 →	+0.518	+0.132	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023058 vs ZNF831 — BRCA

Explore this scatter interactively →