Adaptation of signaling pathway

Across TCGA patient cohorts, RNA activity of the Adaptation of signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARRB1_S412, DOCK2, and RDH11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adaptation of signaling pathway activity versus ARRB1_S412 in OV (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARRB1_S412 →	+1.723	+0.208	<.001	<.001	3	5
HNSC	DOCK2 →	+0.475	+0.174	<.001	<.001	3	4
PDAC	RDH11 →	+0.499	+0.180	<.001	<.001	3	3
BRCA	RGS14_S203 →	+0.950	+0.149	<.001	<.001	3	3
HNSC	STK10 →	+0.374	+0.169	<.001	.001	3	3
GBM	STX7 →	+0.273	+0.460	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023058 vs ARRB1_S412 — OV

Explore this scatter interactively →