Adaptation of signaling pathway

Across TCGA cell cohorts, RNA activity of the Adaptation of signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABPB1, TUBGCP3, and HERPUD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GABPB1 grouped by Adaptation of signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GABPB1 →	+0.428	+0.322	<.001	<.001	3	5
BLOOD_Myeloma	TUBGCP3 →	+0.296	+0.135	.007	.003	3	4
LIVER	HERPUD1 →	-0.228	-0.144	<.001	.003	3	4
KIDNEY	SOX4 →	+0.264	+0.181	.001	.004	3	4
BREAST	USP17L1 →	+0.172	+0.117	.007	.007	3	4
OVARY	ADCY2 →	+0.137	+0.164	.007	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GABPB1 by Adaptation of signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →