CD40 signaling pathway

Across TCGA patient cohorts, RNA activity of the CD40 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARVG, IL4I1, and SIRT3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CD40 signaling pathway activity versus PARVG in GBM (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PARVG →	+0.569	+0.089	<.001	<.001	3	9
OV	IL4I1 →	+0.648	+0.035	<.001	.002	3	9
BRCA	SIRT3 →	-0.557	-0.054	<.001	<.001	3	9
BRCA	SAMSN1_S23 →	+0.787	+0.038	<.001	.003	3	8
UCEC	SKAP2 →	+0.563	+0.087	<.001	.004	3	8
BRCA	TYROBP →	+0.853	+0.055	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023035 vs PARVG — GBM

Explore this scatter interactively →