CD40 signaling pathway

Across TCGA patient cohorts, RNA activity of the CD40 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMK1, EMP3, and STAC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, CD40 signaling pathway activity versus LIMK1 in OV (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LIMK1 →	+0.651	+0.629	.001	.001	3	3
OV	EMP3 →	+0.491	+0.406	.006	.002	3	3
OV	STAC3 →	+0.547	+0.595	.001	.002	3	3
OV	MARCO →	+1.247	+0.490	.003	.009	3	3
OV	LINC01943 →	+0.511	+0.477	.003	.004	3	3
OV	LAG3 →	+0.780	+0.641	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023035 vs LIMK1 — OV

Explore this scatter interactively →