CD40 signaling pathway

Across TCGA cell cohorts, RNA activity of the CD40 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFT57, ATP6V1C1, and RNF149, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFT57 grouped by CD40 signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFT57 →	-1.768	-1.074	.008	<.001	3	4
LARGE_INTESTINE	ATP6V1C1 →	+0.479	+0.810	.007	.002	3	4
SOFT_TISSUE	RNF149 →	-0.748	-1.296	.009	.007	3	3
UPPER_AERODIGESTIVE_TRACT	PRTN3 →	+0.166	+1.304	.004	.004	3	3
BLOOD_Leukemia	MPC1 →	+1.248	+1.145	.001	.006	3	3
STOMACH	NACC2 →	-1.365	-1.174	.002	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFT57 by CD40 signaling pathway activity — SOFT_TISSUE

Explore this box plot interactively →