Signal transduction involved in regulation of gene expression

Across TCGA patient cohorts, RNA activity of the Signal transduction involved in regulation of gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SELENBP1, RRP36_S73, and NUP153_T699, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction involved in regulation of gene expression activity versus SELENBP1 in UCEC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SELENBP1 →	+0.688	+0.079	<.001	.006	3	5
OV	RRP36_S73 →	-0.702	-0.043	.002	.002	3	5
BRCA	NUP153_T699 →	-0.642	-0.030	.001	.004	3	5
BRCA	REXO4 →	-0.337	-0.039	.004	.001	3	5
CCRCC	ZNF622 →	-0.248	-0.050	<.001	<.001	3	5
BRCA	DGCR8 →	-0.138	-0.027	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023019 vs SELENBP1 — UCEC

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