Signal transduction involved in regulation of gene expression

Across TCGA patient cohorts, RNA activity of the Signal transduction involved in regulation of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BEST1, PLA2G10, and ANXA9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction involved in regulation of gene expression activity versus BEST1 in LUAD (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BEST1 →	-0.342	-0.626	<.001	<.001	3	4
LUAD	PLA2G10 →	+0.970	+0.486	.001	.002	3	4
UCEC	ANXA9 →	+0.817	+0.312	.005	.004	3	4
LSCC	SEPTIN6 →	-0.583	-0.740	<.001	.002	3	4
HNSC	PTTG4P →	-0.552	-0.358	.001	.007	3	3
CCRCC	RBM25 →	-0.250	-0.195	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023019 vs BEST1 — LUAD

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