Signal transduction involved in regulation of gene expression

Across TCGA cell cohorts, RNA activity of the Signal transduction involved in regulation of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF138, STOML2, and SMIM13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF138 grouped by Signal transduction involved in regulation of gene expression-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF138 →	+0.783	+0.987	<.001	<.001	3	5
LIVER	STOML2 →	+0.703	+1.430	.002	.002	3	4
KIDNEY	SMIM13 →	+0.721	+1.164	.002	.002	3	4
OESOPHAGUS	RIMS4 →	+1.505	+0.905	.008	.009	3	4
OESOPHAGUS	PMS2 →	+0.857	+1.037	.002	.006	3	4
OESOPHAGUS	EEF1E1 →	+1.027	+1.296	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF138 by Signal transduction involved in regulation of gene expression activity — LARGE_INTESTINE

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