Signal transduction involved in regulation of gene expression

Across TCGA cell cohorts, RNA activity of the Signal transduction involved in regulation of gene expression pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3BP4, DLAT, and CAMK2N1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SH3BP4 grouped by Signal transduction involved in regulation of gene expression-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SH3BP4 →	-0.148	-0.178	.001	.003	3	5
OVARY	DLAT →	-0.228	-0.236	.001	.003	3	4
BONE	CAMK2N1 →	-0.318	-0.304	.006	.003	3	4
PANCREAS	URAD →	-0.157	-0.171	.004	<.001	3	4
KIDNEY	LRP2 →	-0.227	-0.314	.002	<.001	3	4
OESOPHAGUS	MADD →	+0.102	+0.265	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SH3BP4 by Signal transduction involved in regulation of gene expression activity — LUNG_NSCLC_LUAD

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