Signal transduction involved in regulation of gene expression

Across TCGA cell cohorts, RNA activity of the Signal transduction involved in regulation of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD3, ANXA2, and SDC4, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction involved in regulation of gene expression activity versus SMAD3 in SKIN (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SMAD3 →	+1.921	+0.265	<.001	<.001	3	11
SKIN	ANXA2 →	+1.287	+0.210	<.001	<.001	3	8
SKIN	SDC4 →	+1.527	+0.199	<.001	<.001	3	8
OVARY	ARHGAP29 →	+1.953	+0.195	.002	.001	3	7
LUNG_SCLC	JUP →	+1.973	+0.289	<.001	<.001	3	7
CNS	HMGA1 →	+1.312	+0.151	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0023019 vs SMAD3 — SKIN

Explore this scatter interactively →