Signal transduction involved in regulation of gene expression

Across TCGA cell cohorts, RNA activity of the Signal transduction involved in regulation of gene expression pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1L2, NUDT11, and NEO1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH1L2 grouped by Signal transduction involved in regulation of gene expression-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH1L2 →	+0.228	+0.318	.008	.003	3	3
LUNG_NSCLC_LUAD	NUDT11 →	+0.205	+0.245	.006	<.001	3	2
LUNG_NSCLC_LUAD	NEO1 →	+0.337	+0.311	.007	.001	3	2
LARGE_INTESTINE	INO80B →	+0.280	+0.260	.002	.005	3	2
LARGE_INTESTINE	MAP4K3 →	+0.220	+0.325	.009	.007	2	3
LARGE_INTESTINE	SOHLH2 →	-0.237	-0.375	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH1L2 by Signal transduction involved in regulation of gene expression activity — LARGE_INTESTINE

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