Respiratory electron transport chain

Across TCGA patient cohorts, RNA activity of the Respiratory electron transport chain pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYEF2, LRP2BP, and RN7SKP160, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory electron transport chain activity versus MYEF2 in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYEF2 →	-0.754	-0.188	.002	.001	3	6
LUAD	LRP2BP →	-0.543	-0.197	<.001	<.001	3	5
LUAD	RN7SKP160 →	-0.476	-0.171	.003	.005	3	5
HNSC	FIG4 →	-0.333	-0.162	.006	.004	3	4
LUAD	COLCA1 →	-1.146	-0.245	<.001	<.001	3	4
OV	TRIM24 →	-0.387	-0.174	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022904 vs MYEF2 — LSCC

Explore this scatter interactively →