Respiratory electron transport chain

Across TCGA cell cohorts, RNA activity of the Respiratory electron transport chain pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPP1, ATP2C2, and FBLN7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, INPP1 grouped by Respiratory electron transport chain-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	INPP1 →	-1.252	-0.230	<.001	.009	2	6
BREAST	ATP2C2 →	+1.929	+0.329	<.001	<.001	3	5
CNS	FBLN7 →	-1.965	-0.228	<.001	.002	3	4
BLOOD_Myeloma	PNPLA6 →	-0.484	-0.350	.006	.003	3	4
LIVER	CLIP2 →	-1.396	-0.358	.003	.009	3	4
LARGE_INTESTINE	PPIAL4A →	-0.074	-0.285	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

INPP1 by Respiratory electron transport chain activity — BREAST

Explore this box plot interactively →