DNA strand elongation

Across TCGA patient cohorts, RNA activity of the DNA strand elongation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZH2, PLK4, and ESCO2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand elongation activity versus EZH2 in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EZH2 →	+1.084	+0.338	<.001	<.001	3	9
OV	PLK4 →	+0.756	+0.317	<.001	<.001	3	9
LSCC	ESCO2 →	+0.890	+0.358	<.001	<.001	3	9
BRCA	CDCA2 →	+1.297	+0.281	<.001	<.001	3	9
LSCC	PARPBP →	+0.947	+0.324	<.001	<.001	3	9
UCEC	KIF4A →	+0.939	+0.243	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022616 vs EZH2 — LSCC

Explore this scatter interactively →