DNA strand elongation

Across TCGA cell cohorts, RNA activity of the DNA strand elongation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YY1, LGALS14, and NAT8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, YY1 grouped by DNA strand elongation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	YY1 →	-0.364	-0.103	.008	.006	3	7
SKIN	LGALS14 →	+0.214	+0.159	<.001	.003	3	6
KIDNEY	NAT8 →	-0.304	-0.149	.003	.001	3	5
BLOOD_Myeloma	SBNO1 →	-0.252	-0.207	.009	.001	3	5
BLOOD_Myeloma	USP3 →	+0.362	+0.252	<.001	<.001	3	5
BREAST	TLX3 →	+0.085	+0.195	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YY1 by DNA strand elongation activity — BREAST

Explore this box plot interactively →