DNA strand elongation

Across TCGA cell cohorts, RNA activity of the DNA strand elongation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTBN4, MRPL15, and ATP5PF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTBN4 grouped by DNA strand elongation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPTBN4 →	+0.375	+0.122	.001	.001	3	4
OESOPHAGUS	MRPL15 →	-0.748	-0.207	.002	.002	3	4
OESOPHAGUS	ATP5PF →	-0.460	-0.121	.004	.006	3	4
OESOPHAGUS	TOR3A →	-0.732	-0.155	.004	.001	3	4
OESOPHAGUS	LAMC2 →	+2.606	+0.199	<.001	<.001	3	4
BLOOD_Leukemia	LTB4R2 →	+1.130	+0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTBN4 by DNA strand elongation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →