DNA strand elongation

Across TCGA cell cohorts, RNA activity of the DNA strand elongation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C17orf75, LIG3, and NLE1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA strand elongation activity versus C17orf75 in CNS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C17orf75 →	+0.889	+0.258	.001	.001	3	7
BLOOD_Leukemia	LIG3 →	+0.398	+0.121	.006	.004	2	8
LUNG_SCLC	NLE1 →	+0.451	+0.127	.001	.007	3	7
OESOPHAGUS	MRE11 →	+0.842	+0.216	.006	.002	2	7
BLOOD_Lymphoma	YEATS2 →	+0.793	+0.237	<.001	<.001	3	6
LUNG_NSCLC_LUSC	USP39 →	+0.743	+0.248	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022616 vs C17orf75 — CNS

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