Gland morphogenesis

Across TCGA patient cohorts, RNA activity of the Gland morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, SORBS3, and VIM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gland morphogenesis activity versus KANK2 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2 →	+0.590	+0.050	<.001	<.001	3	9
UCEC	SORBS3 →	+0.627	+0.058	<.001	.003	3	8
BRCA	VIM →	+0.495	+0.049	<.001	<.001	3	8
BRCA	CAVIN3 →	+0.762	+0.054	<.001	<.001	3	8
OV	CNRIP1 →	+0.784	+0.073	<.001	<.001	3	8
OV	FHL3 →	+0.780	+0.060	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022612 vs KANK2 — BRCA

Explore this scatter interactively →