Gland morphogenesis

Across TCGA cell cohorts, RNA activity of the Gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARS2, ATP8B3, and ZNF543, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARS2 grouped by Gland morphogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MARS2 →	+0.840	+1.227	<.001	.002	3	5
LUNG_NSCLC_LUSC	ATP8B3 →	-2.511	-1.612	<.001	<.001	3	4
LUNG_SCLC	ZNF543 →	+0.581	+0.865	.006	.001	3	4
LUNG_SCLC	POLR1A →	+0.435	+0.744	.009	.008	2	5
PANCREAS	LETM1 →	+0.778	+0.985	.003	.007	3	4
BLOOD_Lymphoma	H2BC6 →	+0.634	+1.693	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARS2 by Gland morphogenesis activity — OVARY

Explore this box plot interactively →