Gland morphogenesis

Across TCGA cell cohorts, RNA activity of the Gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEC, RALGDS, and YWHAZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gland morphogenesis activity versus PLEC in LIVER (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PLEC →	+1.568	+0.447	<.001	.003	3	6
BONE	RALGDS →	+1.491	+0.284	.005	.001	3	5
STOMACH	YWHAZ →	+1.061	+0.313	.006	.003	3	5
LIVER	UGCG →	+2.638	+0.478	<.001	.001	3	4
BLOOD_Leukemia	SLC9A7 →	+1.343	+0.173	.005	.006	2	5
LIVER	CAV2 →	+2.424	+0.386	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022612 vs PLEC — LIVER

Explore this scatter interactively →