Regulation of cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM10, SCAF1, and TTYH3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell morphogenesis activity versus ADAM10 in LARGE_INTESTINE (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM10 →	+1.284	+0.037	<.001	.004	3	13
LARGE_INTESTINE	SCAF1 →	+1.083	+0.061	<.001	<.001	3	12
STOMACH	TTYH3 →	+1.575	+0.048	<.001	.001	3	12
SOFT_TISSUE	TRIOBP →	+1.037	+0.030	<.001	<.001	3	12
BONE	PLBD2 →	+0.788	+0.025	.006	.008	3	12
BONE	TTC7A →	+1.692	+0.056	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022604 vs ADAM10 — LARGE_INTESTINE

Explore this scatter interactively →