Regulation of cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of cell morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAV2, ANXA2, and TBC1D2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell morphogenesis activity versus CAV2 in OESOPHAGUS (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CAV2 →	+1.967	+0.151	.002	.004	3	7
LUNG_NSCLC_LUSC	ANXA2 →	+2.217	+0.337	<.001	<.001	3	7
LARGE_INTESTINE	TBC1D2 →	+1.219	+0.153	<.001	<.001	3	7
LUNG_NSCLC_LUSC	CAVIN1 →	+5.952	+0.295	.002	.004	3	7
OESOPHAGUS	F3 →	+3.695	+0.164	.001	.003	3	7
LUNG_NSCLC_LUSC	PLK2 →	+5.747	+0.287	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022604 vs CAV2 — OESOPHAGUS

Explore this scatter interactively →