Ovulation cycle process

Across TCGA patient cohorts, RNA activity of the Ovulation cycle process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTN1, FKBP7, and MMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ovulation cycle process activity versus ACTN1 in UCEC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTN1 →	+0.466	+0.061	.001	<.001	3	8
UCEC	FKBP7 →	+0.646	+0.078	<.001	<.001	3	8
CCRCC	MMP2 →	+0.737	+0.051	<.001	<.001	3	8
CCRCC	PDLIM5 →	+0.553	+0.029	.002	.006	3	8
BRCA	FERMT2 →	+0.527	+0.036	<.001	<.001	3	8
OV	CD248 →	+0.734	+0.038	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022602 vs ACTN1 — UCEC

Explore this scatter interactively →