Ovulation cycle process

Across TCGA cell cohorts, RNA activity of the Ovulation cycle process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP3, MEX3B, and LRP2BP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ovulation cycle process activity versus CASP3 in BLOOD_Lymphoma (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CASP3 →	+1.194	+1.193	.001	<.001	3	6
BLOOD_Lymphoma	MEX3B →	+0.757	+0.968	.008	.003	2	5
PANCREAS	LRP2BP →	+0.358	+1.479	.001	.001	3	4
BREAST	PHF10 →	+1.059	+1.099	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	CCDC103 →	-0.649	-1.414	.001	.002	3	4
LUNG_NSCLC_LUAD	LPCAT2 →	-1.257	-0.948	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022602 vs CASP3 — BLOOD_Lymphoma

Explore this scatter interactively →