Negative regulation of cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, HCK, and TLR8, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-cell adhesion activity versus CSF2RB in SCLC (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CSF2RB →	+2.042	+0.130	<.001	<.001	3	34
SARC	HCK →	+2.120	+0.040	<.001	<.001	3	34
LAML	TLR8 →	+3.140	+0.048	<.001	<.001	3	34
UVM	GBP1 →	+2.571	+0.030	<.001	<.001	3	34
SCLC	SRGN →	+2.098	+0.135	<.001	<.001	3	34
LAML	FGL2 →	+2.717	+0.047	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022408 vs CSF2RB — SCLC

Explore this scatter interactively →