Negative regulation of cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIN3, SAMSN1_S23, and SERPINB9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-cell adhesion activity versus RIN3 in GBM (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RIN3 →	+0.497	+0.063	<.001	<.001	3	10
UCEC	SAMSN1_S23 →	+0.886	+0.058	<.001	<.001	3	10
BRCA	SERPINB9 →	+0.572	+0.040	<.001	<.001	3	10
GBM	SKAP2 →	+0.815	+0.066	<.001	<.001	3	10
OV	SPN →	+1.000	+0.043	<.001	<.001	3	10
LSCC	STK10 →	+0.454	+0.065	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022408 vs RIN3 — GBM

Explore this scatter interactively →