Negative regulation of cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHE, THSD7A, and QKI, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-cell adhesion activity versus SHE in COAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SHE →	+0.414	+0.549	<.001	.003	3	3
COAD	THSD7A →	+0.418	+0.805	<.001	<.001	3	3
BRCA	QKI →	+0.880	+0.570	.004	.008	3	2
BRCA	NPR3 →	+1.078	+0.477	.006	.002	3	2
BRCA	CLIP4 →	+1.375	+0.618	.006	.006	3	2
BRCA	HLX →	+0.380	+0.671	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022408 vs SHE — COAD

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