Negative regulation of cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf96, GCG, and PARP10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C20orf96 grouped by Negative regulation of cell-cell adhesion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	C20orf96 →	-0.943	-0.353	<.001	.001	3	5
PANCREAS	GCG →	+0.161	+0.209	.003	.001	3	5
CNS	PARP10 →	+1.343	+0.184	.002	.002	3	5
BREAST	TBC1D20 →	+0.968	+0.123	<.001	.001	3	4
LUNG_SCLC	CITED1 →	-1.657	-0.168	.005	.007	2	5
LUNG_SCLC	SLC16A3 →	+4.209	+0.280	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C20orf96 by Negative regulation of cell-cell adhesion activity — LIVER

Explore this box plot interactively →