Negative regulation of cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APEX1, POLR3K, and WDFY1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-cell adhesion activity versus APEX1 in BLOOD_Myeloma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	APEX1 →	+0.712	+0.205	.001	.009	2	6
STOMACH	POLR3K →	+0.947	+0.180	.005	.009	3	5
SKIN	WDFY1 →	+1.718	+0.357	<.001	<.001	3	5
LARGE_INTESTINE	PRDM1 →	+0.631	+0.152	.006	.001	3	4
LIVER	CPSF6 →	+0.558	+0.329	.006	.001	3	4
LIVER	SNRNP40 →	+0.704	+0.319	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022408 vs APEX1 — BLOOD_Myeloma

Explore this scatter interactively →