Molting cycle process

Across TCGA patient cohorts, RNA activity of the Molting cycle process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP7, MPRIP, and CNPY4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Molting cycle process activity versus FKBP7 in BRCA (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FKBP7 →	+0.436	+0.027	<.001	<.001	3	8
COAD	MPRIP →	+0.333	+0.035	<.001	<.001	3	7
UCEC	CNPY4 →	+0.617	+0.077	<.001	<.001	3	7
UCEC	HMCN1 →	+0.637	+0.068	<.001	.001	3	6
LSCC	LAMB1 →	+0.410	+0.058	<.001	<.001	3	6
COAD	RAI14 →	+0.427	+0.024	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022404 vs FKBP7 — BRCA

Explore this scatter interactively →