Molting cycle process

Across TCGA patient cohorts, RNA activity of the Molting cycle process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NF1, KLHL6, and TRGV9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Molting cycle process activity versus NF1 in LSCC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NF1 →	+0.621	+0.221	<.001	<.001	3	6
UCEC	KLHL6 →	-0.806	-0.340	.001	<.001	3	5
HNSC	TRGV9 →	-0.717	-0.226	.005	<.001	3	5
UCEC	TBXAS1 →	-0.867	-0.315	<.001	<.001	3	5
LSCC	CHMP3 →	+0.344	+0.174	<.001	.002	3	5
CCRCC	RPL39 →	+0.457	+0.747	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0022404 vs NF1 — LSCC

Explore this scatter interactively →